Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease
نویسندگان
چکیده
INTRODUCTION Patients with long-standing ulcerative colitis (UC) and Crohn’s disease of the colon are at an increased risk of developing colorectal neoplasia (dysplasia and colorectal carcinoma). The association of UC with colorectal carcinoma was first recognized in the 1920s [1]. In inflammatory bowel disease (IBD) the development of colorectal carcinoma (CRC) occurs through an inflammation-dysplasia-carcinoma pathway [2]. In contrast to patients with sporadic CRC, individuals with IBD-related CRC have an increased incidence of synchronous malignancies, an absence of adenomatous polyps preceding the development of carcinoma, and a more rapid rate of progression of colonic mucosa to dysplasia. In this article we will review the epidemiology, risk factors, detection methods, surveillance and management issues of colorectal neoplasia in IBD patients. INFLAMMATORY BOWEL DISEASE: A PRACTICAL APPROACH, SERIES #64
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